Article
Germline and somatic genetic variations of TNFAIP3 in lymphoma complicating primary Sjogren's syndrome.
Blood - 12 Dec 2013
Nocturne Gaetane, Boudaoud Saida, Miceli-Richard Corinne, Viengchareun Say, Lazure Thierry, Nititham Joanne, Taylor Kimberly E, Ma Averil, Busato Florence, Melki Judith, Lessard Christopher J, Sivils Kathy L, Dubost Jean-Jacques, Hachulla Eric, Gottenberg Jacques Eric, Lombès Marc, Tost Jorg, Criswell Lindsey A, Mariette Xavier
Abstract excerpt
Several autoimmune diseases, including primary Sjögren's syndrome (pSS), are associated with an increased risk for lymphoma. Polymorphisms of TNFAIP3, which encodes the A20 protein that plays a key role in controlling nuclear factor κB activation, have been associated with several autoimmune diseases. Somatic mutations of TNFAIP3 have been observed in the mucosa-associated lymphoid tissue lymphoma subtype...
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