Article
Exome-sequencing in a large population-based study reveals a rare Asn396Ser variant in the LIPG gene associated with depressive symptoms.
Molecular psychiatry - 1 Apr 2017
Amin N, Jovanova O, Adams H H H, Dehghan A, Kavousi M, Vernooij M W, Peeters R P, de Vrij F M S, van der Lee S J, van Rooij J G J, van Leeuwen E M, Chaker L, Demirkan A, Hofman A, Brouwer R W W, Kraaij R, Willems van Dijk K, Hankemeier T, van Ijcken W F J, Uitterlinden A G, Niessen W J, Franco O H, Kushner S A, Ikram M A, Tiemeier H, van Duijn C M
Abstract excerpt
Despite a substantial genetic component, efforts to identify common genetic variation underlying depression have largely been unsuccessful. In the current study we aimed to identify rare genetic variants that might have large effects on depression in the general population. Using high-coverage exome-sequencing, we studied the exonic variants in 1265 individuals from the Rotterdam study (RS), who were assessed for...
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