Article
A rare missense variant in RCL1 segregates with depression in extended families.
Molecular psychiatry - 1 May 2018
Amin N, de Vrij F M S, Baghdadi M, Brouwer R W W, van Rooij J G J, Jovanova O, Uitterlinden A G, Hofman A, Janssen H L A, Darwish Murad S, Kraaij R, Stedehouder J, van den Hout M C G N, Kros J M, van IJcken W F J, Tiemeier H, Kushner S A, van Duijn C M
Abstract excerpt
Depression is the most prevalent psychiatric disorder with a complex and elusive etiology that is moderately heritable. Identification of genes would greatly facilitate the elucidation of the biological mechanisms underlying depression, however, its complex etiology has proved to be a major bottleneck in the identification of its genetic risk factors, especially in genome-wide association-like studies. In this...
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