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Article

Targeted exome sequencing identifies five novel loci at genome-wide significance for modulating antidepressant response in patients with major depressive disorder.

Translational psychiatry - 23 Jan 2020

Xu Zhi, Xie Chunming, Xia Lu, Yuan Yonggui, Zhu Hong, Huang Xiaofa, Li Caihua, Tao Yu, Qu Xiaoxiao, Zhang Fengyu, Zhang Zhijun

Abstract excerpt

In order to determine the role of single nucleotide variants (SNVs) in modulating antidepressant response, we conducted a study, consisting of 929 major depressive disorder (MDD) patients, who were treated with antidepressant drugs (drug-only) or in combination with a repetitive transcranial magnetic stimulation (plus-rTMS), followed by targeted exome sequencing analysis. We found that the "plus-rTMS" patients...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32066657
DOI: 10.1038/s41398-020-0689-x
PMCID: PMC7026085

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