Article
De Novo Characterization of Genes That Contribute to High-Level Ciprofloxacin Resistance in Escherichia coli.
Antimicrobial agents and chemotherapy - 1 Oct 2016
Tran Thu, Ran Qinghong, Ostrer Lev, Khodursky Arkady
Abstract excerpt
Sensitization of resistant bacteria to existing antibiotics depends on the identification of candidate targets whose activities contribute to resistance. Using a transposon insertion library in an Escherichia coli mutant that was 2,000 times less susceptible to ciprofloxacin than its parent and the relative fitness scores, we identified 19 genes that contributed to the acquired ciprofloxacin resistance and mapped...
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