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Article

LNK/SH2B3 Loss of Function Promotes Atherosclerosis and Thrombosis.

Circulation research - 2 Sept 2016

Wang Wei, Tang Yang, Wang Ying, Tascau Liana, Balcerek Joanna, Tong Wei, Levine Ross L, Welch Carrie, Tall Alan R, Wang Nan

Abstract excerpt

RATIONALE: Human genome-wide association studies have revealed novel genetic loci that are associated with coronary heart disease. One such locus resides in LNK/SH2B3, which in mice is expressed in hematopoietic cells and suppresses thrombopoietin signaling via its receptor myeloproliferative leukemia virus oncogene. However, the mechanisms underlying the association of LNK single-nucleotide polymorphisms with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27430239
DOI: 10.1161/CIRCRESAHA.116.308955
PMCID: PMC5016083

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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