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Article

LNK/SH2B3 loss of function increases susceptibility to murine and human atrial fibrillation.

Cardiovascular research - 2 Jul 2024

Murphy Matthew B, Yang Zhenjiang, Subati Tuerdi, Farber-Eger Eric, Kim Kyungsoo, Blackwell Daniel J, Fleming Matthew R, Stark Joshua M, Van Amburg Joseph C, Woodall Kaylen K, Van Beusecum Justin P, Agrawal Vineet, Smart Charles D, Pitzer Ashley, Atkinson James B, Fogo Agnes B, Bastarache Julie A, Kirabo Annet, Wells Quinn S, Madhur Meena S, Barnett Joey V, Murray Katherine T

Abstract excerpt

AIMS: The lymphocyte adaptor protein (LNK) is a negative regulator of cytokine and growth factor signalling. The rs3184504 variant in SH2B3 reduces LNK function and is linked to cardiovascular, inflammatory, and haematologic disorders, including stroke. In mice, deletion of Lnk causes inflammation and oxidative stress. We hypothesized that Lnk-/- mice are susceptible to atrial fibrillation (AF) and that rs3184504...

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Source

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Identifiers

PMID: 38377486
DOI: 10.1093/cvr/cvae036
PMCID: PMC11218690

Genes

SH2B3
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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