Article
p21 mediates macrophage reprogramming through regulation of p50-p50 NF-κB and IFN-β.
The Journal of clinical investigation - 1 Aug 2016
Rackov Gorjana, Hernández-Jiménez Enrique, Shokri Rahman, Carmona-Rodríguez Lorena, Mañes Santos, Álvarez-Mon Melchor, López-Collazo Eduardo, Martínez-A Carlos, Balomenos Dimitrios
Abstract excerpt
M1 and M2 macrophage phenotypes, which mediate proinflammatory and antiinflammatory functions, respectively, represent the extremes of immunoregulatory plasticity in the macrophage population. This plasticity can also result in intermediate macrophage states that support a balance between these opposing functions. In sepsis, M1 macrophages can compensate for hyperinflammation by acquiring an M2-like...
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