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Article

Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells

16 Apr 2012

Abstract excerpt

Malignant progression in cancer requires populations of tumor-initiating cells (TICs) endowed with unlimited self renewal, survival under stress, and establishment of distant metastases. Additionally, the acquisition of invasive properties driven by epithelial-mesenchymal transition (EMT) is critical for the evolution of neoplastic cells into fully metastatic populations. Here, we characterize 2 human cellular...

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PMID: 22505459
DOI: 10.1172/jci59218

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