Article
Adult body mass index and risk of ovarian cancer by subtype: a Mendelian randomization study.
International journal of epidemiology - 1 Jun 2016
Dixon Suzanne C, Nagle Christina M, Thrift Aaron P, Pharoah Paul Dp, Pearce Celeste Leigh, Zheng Wei, Painter Jodie N, Chenevix-Trench Georgia, Fasching Peter A, Beckmann Matthias W, Lambrechts Diether, Vergote Ignace, Lambrechts Sandrina, Van Nieuwenhuysen Els, Rossing Mary Anne, Doherty Jennifer A, Wicklund Kristine G, Chang-Claude Jenny, Rudolph Anja, Moysich Kirsten B, Odunsi Kunle, Goodman Marc T, Wilkens Lynne R, Thompson Pamela J, Shvetsov Yurii B, Dörk Thilo, Park-Simon Tjoung-Won, Hillemanns Peter, Bogdanova Natalia, Butzow Ralf, Nevanlinna Heli, Pelttari Liisa M, Leminen Arto, Modugno Francesmary, Ness Roberta B, Edwards Robert P, Kelley Joseph L, Heitz Florian, Karlan Beth Y, Kjær Susanne K, Høgdall Estrid, Jensen Allan, Goode Ellen L, Fridley Brooke L, Cunningham Julie M, Winham Stacey J, Giles Graham G, Bruinsma Fiona, Milne Roger L, Southey Melissa C, Hildebrandt Michelle A T, Wu Xifeng, Lu Karen H, Liang Dong, Levine Douglas A, Bisogna Maria, Schildkraut Joellen M, Berchuck Andrew, Cramer Daniel W, Terry Kathryn L, Bandera Elisa V, Olson Sara H, Salvesen Helga B, Thomsen Liv Cecilie, Kopperud Reidun K, Bjorge Line, Kiemeney Lambertus A, Massuger Leon F A G, Pejovic Tanja, Cook Linda S, Le Nhu D, Swenerton Kenneth D, Brooks-Wilson Angela, Kelemen Linda E, Lubiński Jan, Huzarski Tomasz, Gronwald Jacek, Menkiszak Janusz, Wentzensen Nicolas, Brinton Louise, Yang Hannah, Lissowska Jolanta, Høgdall Claus K, Lundvall Lene, Song Honglin, Tyrer Jonathan P, Campbell Ian, Eccles Diana, Paul James, Glasspool Rosalind, Siddiqui Nadeem, Whittemore Alice S, Sieh Weiva, McGuire Valerie, Rothstein Joseph H, Narod Steven A, Phelan Catherine, Risch Harvey A, McLaughlin John R, Anton-Culver Hoda, Ziogas Argyrios, Menon Usha, Gayther Simon A, Ramus Susan J, Gentry-Maharaj Aleksandra, Wu Anna H, Pike Malcolm C, Tseng Chiu-Chen, Kupryjanczyk Jolanta, Dansonka-Mieszkowska Agnieszka, Budzilowska Agnieszka, Spiewankiewicz Beata, Webb Penelope M
Abstract excerpt
BACKGROUND: Observational studies have reported a positive association between body mass index (BMI) and ovarian cancer risk. However, questions remain as to whether this represents a causal effect, or holds for all histological subtypes. The lack of association observed for serous cancers may, for instance, be due to disease-associated weight loss. Mendelian randomization (MR) uses genetic markers as proxies for...