Association of germline genetic variants in RFC, IL15 and VDR genes with minimal residual disease in pediatric B-cell precursor ALL.

doi:10.1038/srep29427

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Article

Association of germline genetic variants in RFC, IL15 and VDR genes with minimal residual disease in pediatric B-cell precursor ALL.

Scientific reports - 18 Jul 2016

Dawidowska Małgorzata, Kosmalska Maria, Sędek Łukasz, Szczepankiewicz Aleksandra, Twardoch Magdalena, Sonsala Alicja, Szarzyńska-Zawadzka Bronisława, Derwich Katarzyna, Lejman Monika, Pawelec Katarzyna, Obitko-Płudowska Agnieszka, Pawińska-Wąsikowska Katarzyna, Kwiecińska Kinga, Kołtan Andrzej, Dyla Agnieszka, Grzeszczak Władysław, Kowalczyk Jerzy R, Szczepański Tomasz, Ziętkiewicz Ewa, Witt Michał

Abstract excerpt

Minimal residual disease (MRD) enables reliable assessment of risk in acute lymphoblastic leukemia (ALL). However, little is known on association between MRD status and germline genetic variation. We examined 159 Caucasian (Slavic) patients with pediatric ALL, treated according to ALL-IC-BFM 2002/2009 protocols, in search for association between 23 germline polymorphisms and MRD status at day 15, day 33 and week...

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PMID: 27427275
DOI: 10.1038/srep29427
PMCID: PMC4947903

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