Article
A risk score including microdeletions improves relapse prediction for standard and medium risk precursor B-cell acute lymphoblastic leukaemia in children.
British journal of haematology - 1 Feb 2018
Sutton Rosemary, Venn Nicola C, Law Tamara, Boer Judith M, Trahair Toby N, Ng Anthea, Den Boer Monique L, Dissanayake Anuruddhika, Giles Jodie E, Dalzell Pauline, Mayoh Chelsea, Barbaric Draga, Revesz Tamas, Alvaro Frank, Pieters Rob, Haber Michelle, Norris Murray D, Schrappe Martin, Dalla Pozza Luciano, Marshall Glenn M
Abstract excerpt
To prevent relapse, high risk paediatric acute lymphoblastic leukaemia (ALL) is treated very intensively. However, most patients who eventually relapse have standard or medium risk ALL with low minimal residual disease (MRD) levels. We analysed recurrent microdeletions and other clinical prognostic factors in a cohort of 475 uniformly treated non-high risk precursor B-cell ALL patients with the aim of better...
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