Article
Genotype-Specific Minimal Residual Disease Interpretation Improves Stratification in Pediatric Acute Lymphoblastic Leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Jan 2018
O'Connor David, Enshaei Amir, Bartram Jack, Hancock Jeremy, Harrison Christine J, Hough Rachael, Samarasinghe Sujith, Schwab Claire, Vora Ajay, Wade Rachel, Moppett John, Moorman Anthony V, Goulden Nick
Abstract excerpt
Purpose Minimal residual disease (MRD) and genetic abnormalities are important risk factors for outcome in acute lymphoblastic leukemia. Current risk algorithms dichotomize MRD data and do not assimilate genetics when assigning MRD risk, which reduces predictive accuracy. The aim of our study was to exploit the full power of MRD by examining it as a continuous variable and to integrate it with genetics. Patients...
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