Article
Rare Exome Sequence Variants in CLCN6 Reduce Blood Pressure Levels and Hypertension Risk.
Circulation. Cardiovascular genetics - 1 Feb 2016
Yu Bing, Pulit Sara L, Hwang Shih-Jen, Brody Jennifer A, Amin Najaf, Auer Paul L, Bis Joshua C, Boerwinkle Eric, Burke Gregory L, Chakravarti Aravinda, Correa Adolfo, Dreisbach Albert W, Franco Oscar H, Ehret Georg B, Franceschini Nora, Hofman Albert, Lin Dan-Yu, Metcalf Ginger A, Musani Solomon K, Muzny Donna, Palmas Walter, Raffel Leslie, Reiner Alex, Rice Ken, Rotter Jerome I, Veeraraghavan Narayanan, Fox Ervin, Guo Xiuqing, North Kari E, Gibbs Richard A, van Duijn Cornelia M, Psaty Bruce M, Levy Daniel, Newton-Cheh Christopher, Morrison Alanna C
Abstract excerpt
BACKGROUND: Rare genetic variants influence blood pressure (BP). METHODS AND RESULTS: Whole-exome sequencing was performed on DNA samples from 17 956 individuals of European ancestry and African ancestry (14 497, first-stage discovery and 3459, second-stage discovery) to examine the effect of rare variants on hypertension and 4 BP traits: systolic BP, diastolic BP, pulse pressure, and mean arterial pressure....
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