Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Apoptotic endonuclease EndoG induces alternative splicing of telomerase catalytic subunit hTERT and death of tumor cells

1 Jan 2016

Abstract excerpt

Telomerase activity is known to be regulated by alternative splicing of its catalytic subunit hTERT (human Telomerase Reverse Transcriptase) mRNA. Induction of non-active spliced hTERT leads to inhibition of telomerase activity. However, very little is known about the mechanism of hTERT mRNA alternative splicing. The aim of this study was to determine the role of apoptotic endonuclease EndoG in alternative...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Research and Treatments
Share to Telomeres, Telomerase, and Senescence

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 27420614
DOI: 10.18097/pbmc20166203239

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Apoptotic endonuclease EndoG induces alternative splicing of telomerase catalytic subunit hTERT and death of tumor cellsPMID 27420614Read ↗

Apoptotic endonuclease EndoG regulates alternative splicing of human telomerase catalytic subunit hTERTSemantic proximity Read ↗

Apoptotic endonuclease EndoG inhibits telomerase activity and induces malignant transformation of human CD4+ T cellsSemantic proximity Read ↗

Alternative Splicing of hTERT Pre-mRNA: A Potential Strategy for the Regulation of Telomerase Activity.Semantic proximity Read ↗

Alternative Splicing of Human Telomerase Reverse Transcriptase (hTERT) and Its Implications in Physiological and Pathological ProcessesSemantic proximity Read ↗

An Alternate Splicing Variant of the Human Telomerase Catalytic Subunit Inhibits Telomerase ActivitySemantic proximity Read ↗

Conservation of the pro-apoptotic nuclease activity of endonuclease G in unicellular trypanosomatid parasitesSemantic proximity Read ↗

Regulation of Telomerase Alternative Splicing: A Target for ChemotherapySemantic proximity Read ↗

Characterization of novel alternative splicing sites in human telomerase reverse transcriptase (hTERT): analysis of expression and mutual correlation in mRNA isoforms from normal and tumour tissues.Semantic proximity Read ↗

Complicated RNA splicing of chicken telomerase reverse transcriptase revealed by profiling cells both positive and negative for telomerase activity.Semantic proximity Read ↗

Effect of antisense human telomerase RNA on malignant phenotypes of gastric carcinoma.Semantic proximity Read ↗

Antisense telomerase treatment: induction of two distinct pathways, apoptosis and differentiationSemantic proximity Read ↗

Alternatively spliced variant deleting exons 7 and 8 of the human telomerase reverse transcriptase gene is dominantly expressed in the uterus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.