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Apoptotic endonuclease EndoG inhibits telomerase activity and induces malignant transformation of human CD4+ T cells

1 Jan 2017

Abstract excerpt

Telomerase activity is regulated by an alternative splicing of mRNA of the telomerase catalytic subunit hTERT (human telomerase reverse transcriptase). Increased expression of the inactive spliced hTERT results in inhibition of telomerase activity. Little is known about the mechanism of hTERT mRNA alternative splicing. This study was aimed at determining the effect of an apoptotic endonuclease G (EndoG) on...

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PMID: 28320284
DOI: 10.1134/s0006297917010035

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