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Article

Antisense telomerase treatment: induction of two distinct pathways, apoptosis and differentiation

1 Jul 1998

Abstract excerpt

ABSTRACT Telomerase, the enzyme that elongates telomeric DNA (TTAGGG) n , may be involved in cellular immortality and oncogenesis. To investigate the effect of inhibition of telomerase on tumor cells, we transfected the antisense vector against the human telomerase RNA into human malignant glioma cells exhibiting telomerase activity. After 30 doublings, some subpopulations of transfectants expressed a high level...

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PMID: 9657520
DOI: 10.1096/fasebj.12.10.801

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