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Regulation of Telomerase Alternative Splicing: A Target for Chemotherapy

1 Apr 2013

Abstract excerpt

Telomerase is present in human cancer cells but absent in most somatic tissues. The messenger RNA of human telomerase (hTERT) is alternatively spliced into mostly nonfunctional products. We sought to understand splicing so that we could decrease functional splice isoforms to reduce telomerase activity in order to complement direct enzyme inhibition. Unexpectedly, minigenes containing hTERT exons 5-10 flanked by...

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Share to Advanced biosensing and bioanalysis techniques
Share to RNA Interference and Gene Delivery
Share to Telomeres, Telomerase, and Senescence

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PMID: 23562158
DOI: 10.1016/j.celrep.2013.03.011

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