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Article

miR-146a-5p plays an essential role in the aberrant epithelial-fibroblast cross-talk in COPD.

The European respiratory journal - 1 May 2017

Osei Emmanuel T, Florez-Sampedro Laura, Tasena Hataitip, Faiz Alen, Noordhoek Jacobien A, Timens Wim, Postma Dirkje S, Hackett Tillie L, Heijink Irene H, Brandsma Corry-Anke

Abstract excerpt

We previously reported that epithelial-derived interleukin (IL)-1α drives fibroblast-derived inflammation in the lung epithelial-mesenchymal trophic unit. Since miR-146a-5p has been shown to negatively regulate IL-1 signalling, we investigated the role of miR-146a-5p in the regulation of IL-1α-driven inflammation in chronic obstructive pulmonary disease (COPD).Human bronchial epithelial (16HBE14o-) cells were...

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Identifiers

PMID: 28546273
DOI: 10.1183/13993003.02538-2016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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