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Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification during Skin Development

14 Jul 2016

Abstract excerpt

An increasing amount of evidence indicates that developmental programs are tightly regulated by the complex interplay between signaling pathways, as well as transcriptional and epigenetic processes. Here, we have uncovered coordination between transcriptional and morphogen cues to specify Merkel cells, poorly understood skin cells that mediate light touch sensations. In murine dorsal skin, Merkel cells are part...

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PMID: 27414999
DOI: 10.1371/journal.pgen.1006151

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Related research

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Research trail→

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Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification during Skin DevelopmentPMID 27414999Read ↗

Dissecting the Roles of Polycomb Repressive Complex 2 Subunits in the Control of Skin Development.Semantic proximity Read ↗

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The Touch Dome Defines an Epidermal Niche Specialized for Mechanosensory SignalingSemantic proximity Read ↗

Epidermal progenitors give rise to Merkel cells during embryonic development and adult homeostasisSemantic proximity Read ↗

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