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Article

A Cascade of Wnt, Eda, and Shh Signaling Is Essential for Touch Dome Merkel Cell Development.

PLoS genetics - 1 Jul 2016

Xiao Ying, Thoresen Daniel T, Miao Lingling, Williams Jonathan S, Wang Chaochen, Atit Radhika P, Wong Sunny Y, Brownell Isaac

Abstract excerpt

The Sonic hedgehog (Shh) signaling pathway regulates developmental, homeostatic, and repair processes throughout the body. In the skin, touch domes develop in tandem with primary hair follicles and contain sensory Merkel cells. The developmental signaling requirements for touch dome specification are largely unknown. We found dermal Wnt signaling and subsequent epidermal Eda/Edar signaling promoted Merkel cell...

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PMID: 27414798
DOI: 10.1371/journal.pgen.1006150
PMCID: PMC4944988

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