Article
Microbiota-Produced Succinate Improves Glucose Homeostasis via Intestinal Gluconeogenesis.
Cell metabolism - 12 Jul 2016
De Vadder Filipe, Kovatcheva-Datchary Petia, Zitoun Carine, Duchampt Adeline, Bäckhed Fredrik, Mithieux Gilles
Abstract excerpt
Beneficial effects of dietary fiber on glucose and energy homeostasis have long been described, focusing mostly on the production of short-chain fatty acids by the gut commensal bacteria. However, bacterial fermentation of dietary fiber also produces large amounts of succinate and, to date, no study has focused on the role of succinate on host metabolism. Here, we fed mice a fiber-rich diet and found that...
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