Article
Nonlinear tumor evolution from dysplastic nodules to hepatocellular carcinoma.
Oncotarget - 10 Jan 2017
Joung Je-Gun, Ha Sang Yun, Bae Joon Seol, Nam Jae-Yong, Gwak Geum-Youn, Lee Hae-Ock, Son Dae-Soon, Park Cheol-Keun, Park Woong-Yang
Abstract excerpt
Dysplastic nodules are premalignant neoplastic nodules found in explanted livers with cirrhosis. Genetic signatures of premalignant dysplastic nodules (DNs) with concurrent hepatocellular carcinoma (HCC) may provide an insight in the molecular evolution of hepatocellular carcinogenesis. We analyzed four patients with multifocal nodular lesions and cirrhotic background by whole-exome sequencing (WES). The genomic...
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