Article
Comprehensive analysis of genetic aberrations linked to tumorigenesis in regenerative nodules of liver cirrhosis.
Journal of gastroenterology - 1 Jul 2019
Kim Soo Ki, Takeda Haruhiko, Takai Atsushi, Matsumoto Tomonori, Kakiuchi Nobuyuki, Yokoyama Akira, Yoshida Kenichi, Kaido Toshimi, Uemoto Shinji, Minamiguchi Sachiko, Haga Hironori, Shiraishi Yuichi, Miyano Satoru, Seno Hiroshi, Ogawa Seishi, Marusawa Hiroyuki
Abstract excerpt
BACKGROUND: Hepatocellular carcinoma (HCC) recurrently develops in cirrhotic liver containing a number of regenerative nodules (RNs). However, the biological tumorigenic potential of RNs is still unclear. To uncover the molecular bases of tumorigenesis in liver cirrhosis, we investigated the genetic aberrations in RNs of cirrhotic tissues using next-generation sequencing. METHODS: We isolated 205 RNs and 7 HCC...
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