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Article

Genomic structures of dysplastic nodule and concurrent hepatocellular carcinoma.

Human pathology - 1 Nov 2018

Lee Minho, Kim Kyung, Kim Shinn Young, Jung Seung-Hyun, Yoon Jonghwan, Kim Min Sung, Park Hyeon-Chun, Jung Eun Sun, Chung Yeun-Jun, Lee Sug Hyung

Abstract excerpt

Although high-grade dysplastic nodule (HGDN) is a preneoplastic lesion that precedes hepatocellular carcinoma (HCC), the genomic structures of HGDN in conjunction with HCC remain elusive. The objective of this study was to identify genomic alterations of HGDN and its difference from HCC that may drive HGDN progression to HCC. We analyzed 16 regions of paired HGDN and HCC from 6 patients using whole-exome...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29949741
DOI: 10.1016/j.humpath.2018.06.026

Genes

CTNNB1
CCND1
ERBB2
MET
PTEN
SETD2
SMO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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