Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The HSA21 gene EURL/C21ORF91 controls neurogenesis within the cerebral cortex and is implicated in the pathogenesis of Down Syndrome

11 Jul 2016

Abstract excerpt

Copy number variations to chromosome 21 (HSA21) cause intellectual disability and Down Syndrome, but our understanding of the HSA21 genetic factors which contribute to fetal brain development remains incomplete. Here, we focussed on the neurodevelopmental functions for EURL (also known as C21ORF91, Refseq Gene ID:54149), a protein-coding gene at the centromeric boundary of the Down Syndrome Critical Region (DSCR)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Congenital heart defects research
Share to Down syndrome and intellectual disability research
Share to Genetics and Neurodevelopmental Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27404227
DOI: 10.1038/srep29514

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The HSA21 gene EURL/C21ORF91 controls neurogenesis within the cerebral cortex and is implicated in the pathogenesis of Down SyndromePMID 27404227Read ↗

ZBTB21 suppresses CRE-mediated transcription to impair synaptic function in Down syndromeSemantic proximity Read ↗

DYRK1A interacts with the REST/NRSF-SWI/SNF chromatin remodelling complex to deregulate gene clusters involved in the neuronal phenotypic traits of Down syndromeSemantic proximity Read ↗

Restoring DSCAM expression rescues neuronal morphology and axon guidance deficits in Down syndromeSemantic proximity Read ↗

Chr21 protein-protein interactions: enrichment in products involved in intellectual disabilities, autism and Late Onset Alzheimer DiseaseSemantic proximity Read ↗

Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s diseaseSemantic proximity Read ↗

Systematic Functional Characterization of Human 21st Chromosome Orthologs in <i>Caenorhabditis elegans</i>Semantic proximity Read ↗

Systematic Functional Characterization of Human 21st Chromosome Orthologs in Caenorhabditis elegans.Semantic proximity Read ↗

Spatiotemporal expression of Rest in the brain of Ts1Cje mouse model of Down syndromeSemantic proximity Read ↗

MED13L and its disease-associated variants influence the dendritic development of cerebral cortical neurons in the mammalian brain.Semantic proximity Read ↗

REST Targets JAK–STAT and HIF-1 Signaling Pathways in Human Down Syndrome Brain and Neural CellsSemantic proximity Read ↗

CECR2, a protein involved in neurulation, forms a novel chromatin remodeling complex with SNF2L.Semantic proximity Read ↗

The role of Down syndrome cell adhesion molecule in Down syndromeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.