Article
CECR2, a protein involved in neurulation, forms a novel chromatin remodeling complex with SNF2L.
Human molecular genetics - 15 Feb 2005
Banting Graham S, Barak Orr, Ames Tanya M, Burnham Amanda C, Kardel Melanie D, Cooch Neil S, Davidson Courtney E, Godbout Roseline, McDermid Heather E, Shiekhattar Ramin
Abstract excerpt
Chromatin remodeling complexes play critical roles in development. Here we describe a transcription factor, CECR2, which is involved in neurulation and chromatin remodeling. CECR2 shows complex alternative splicing, but all variants contain DDT and bromodomain motifs. A mutant mouse line was generated from an embryonic stem cell line containing a genetrap within Cecr2. Reporter gene expression demonstrated Cecr2...
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