Article
Meiotic onset is reliant on spatial distribution but independent of germ cell number in the mouse ovary.
Journal of cell science - 1 Jul 2016
Arora Ripla, Abby Emilie, Ross Adam D J, Cantu Andrea V, Kissner Michael D, Castro Vianca, Ho Hsin-Yi Henry, Livera Gabriel, Laird Diana J
Abstract excerpt
Mouse ovarian germ cells enter meiosis in a wave that propagates from anterior to posterior, but little is known about contribution of germ cells to initiation or propagation of meiosis. In a Ror2 mutant with diminished germ cell number and migration, we find that overall timing of meiotic initiation is delayed at the population level. We use chemotherapeutic depletion to exclude a profoundly reduced number of...
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