Article
Angiopoietin-2 promotes myeloid cell infiltration in a β₂-integrin-dependent manner.
Blood - 3 Nov 2011
Scholz Alexander, Lang Victoria, Henschler Reinhard, Czabanka Marcus, Vajkoczy Peter, Chavakis Emmanouil, Drynski Janina, Harter Patrick N, Mittelbronn Michel, Dumont Daniel J, Plate Karl H, Reiss Yvonne
Abstract excerpt
In human inflammatory diseases, we identified endothelial angiopoietin-2 (Ang-2) expression to be strongly associated with inflammations mediated by myeloid cells but not lymphocytes. To identify the underlying mechanism, we made use of a transgenic mouse model with inducible endothelial cell-specific expression of Ang-2. In this model, in the absence of inflammatory stimuli, long-term expression of Ang-2 led to...
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