Article

FBXO11 deficiency in mice impairs lung development and aggravates cigarette smoke-induced airway fibrosis

2022-05-31

Abstract excerpt

Small airway fibrosis is a common pathology of chronic obstructive pulmonary disease (COPD) and contributes to airflow obstruction. However, the underlying fibrogenic mechanism is poorly understood. Epithelial-mesenchymal transition (EMT) has been proposed as a driver of fibrosis. EMT occurs in the airways of COPD patients and smokers, but it remains elusive whether EMT may contribute to airway fibrosis. We previo...

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Literature Corpus work: 83d1409c-c4bc-586d-9e1c-8adb5bf3d7cc
DOI: 10.1101/2022.05.31.494154

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