Article
Single treatment of VX poisoned guinea pigs with the phosphotriesterase mutant C23AL: Intraosseous versus intravenous injection.
Toxicology letters - 6 Sept 2016
Wille Timo, Neumaier Katharina, Koller Marianne, Ehinger Christina, Aggarwal Nidhi, Ashani Yacov, Goldsmith Moshe, Sussman Joel L, Tawfik Dan S, Thiermann Horst, Worek Franz
Abstract excerpt
The recent attacks with the nerve agent sarin in Syria reveal the necessity of effective countermeasures against highly toxic organophosphorus compounds. Multiple studies provide evidence that a rapid onset of antidotal therapy might be life-saving but current standard antidotal protocols comprising reactivators and competitive muscarinic antagonists show a limited efficacy for several nerve agents. We here set...
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