A search for amino acid substitutions that universally activate response regulators.

doi:10.1046/j.1365-2958.2003.03882.x

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Article

A search for amino acid substitutions that universally activate response regulators.

Molecular microbiology - 1 Feb 2004

Smith Jenny G, Latiolais Jamie A, Guanga Gerald P, Pennington J Daniel, Silversmith Ruth E, Bourret Robert B

Abstract excerpt

Two-component regulatory systems, typically composed of a sensor kinase to detect a stimulus and a response regulator to execute a response, are widely used by microorganisms for signal transduction. Response regulators exhibit a high degree of structural similarity and undergo analogous activating conformational changes upon phosphorylation. The activity of particular response regulators can be increased by...

Topics

Amino Acid Substitution
Bacterial Proteins
Phenotype
Phosphorylation
Protein Binding
Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 14731287
DOI: 10.1046/j.1365-2958.2003.03882.x

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