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Article

A search for amino acid substitutions that universally activate response regulators.

Molecular microbiology - 1 Feb 2004

Smith Jenny G, Latiolais Jamie A, Guanga Gerald P, Pennington J Daniel, Silversmith Ruth E, Bourret Robert B

Abstract excerpt

Two-component regulatory systems, typically composed of a sensor kinase to detect a stimulus and a response regulator to execute a response, are widely used by microorganisms for signal transduction. Response regulators exhibit a high degree of structural similarity and undergo analogous activating conformational changes upon phosphorylation. The activity of particular response regulators can be increased by...

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Identifiers

PMID: 14731287
DOI: 10.1046/j.1365-2958.2003.03882.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A search for amino acid substitutions that universally activate response regulators.PMID 14731287Read ↗

Role of Position K+4 in the Phosphorylation and Dephosphorylation Reaction Kinetics of the CheY Response Regulator.Semantic proximity Read ↗

Genetic analysis of response regulator activation in bacterial chemotaxis suggests an intermolecular mechanism.Semantic proximity Read ↗

Proposed signal transduction role for conserved CheY residue Thr87, a member of the response regulator active-site quintet.Semantic proximity Read ↗

Experimental Analysis of Functional Variation within Protein Families: Receiver Domain Autodephosphorylation Kinetics.Semantic proximity Read ↗

Synthesis and biochemical characterization of a phosphorylated analogue of the response regulator CheB.Semantic proximity Read ↗

Investigation of the role of electrostatic charge in activation of the Escherichia coli response regulator CheY.Semantic proximity Read ↗

Roles of the highly conserved aspartate and lysine residues in the response regulator of bacterial chemotaxis.Semantic proximity Read ↗

Role of the PFXFATG[G/Y] Motif in the Activation of SdrG, a Response Regulator Involved in the Alphaproteobacterial General Stress Response.Semantic proximity Read ↗

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Determinants of chemotactic signal amplification in Escherichia coli.Semantic proximity Read ↗

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