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Article

Antioxidant status and APOE genotype as susceptibility factors for neurodegeneration in Alzheimer's disease and vascular dementia.

Rejuvenation research - 1 Feb 2013

Zito Giancarlo, Polimanti Renato, Panetta Valentina, Ventriglia Mariacarla, Salustri Carlo, Siotto Maria Cristina, Moffa Filomena, Altamura Claudia, Vernieri Fabrizio, Lupoi Domenico, Cassetta Emanuele, Rossini Paolo M, Squitti Rosanna

Abstract excerpt

Different factors interact to develop neurodegeneration in patients with dementia and other neurodegenerative disorders. Oxidative stress and the ε4 allele of apolipoprotein E (ApoE) are associated with significant alteration in lipid metabolism, in turn connected to a variety of neurodegenerative diseases and aging. Thus, a better understanding of the pathogenetic pathways associated with lipid dyshomeostasis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 23216585
DOI: 10.1089/rej.2012.1383
PMCID: PMC3582293

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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