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Article

Functional characterization of chicken TLR5 reveals species-specific recognition of flagellin.

Molecular immunology - 1 Mar 2008

Keestra A Marijke, de Zoete Marcel R, van Aubel Rémon A M H, van Putten Jos P M

Abstract excerpt

Mammalian Toll-like receptor 5 (TLR5) senses flagellin of several bacterial species and activates the innate immune system. The avian TLR repertoire exhibits considerable functional diversity compared to mammalian TLRs and evidence of a functional TLR5 in the avian species is lacking. In the present study we cloned and successfully expressed chicken TLR5 (chTLR5) in HeLa cells, as indicated by laser confocal...

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Identifiers

PMID: 17964652
DOI: 10.1016/j.molimm.2007.09.013

Genes

TLR5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Functional characterization of chicken TLR5 reveals species-specific recognition of flagellin.PMID 17964652Read ↗

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Reconstitution of a functional Toll-like receptor 5 binding site in Campylobacter jejuni flagellin.Semantic proximity Read ↗

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Evasion of Toll-like receptor 5 by flagellated bacteria.Semantic proximity Read ↗

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Innate immune detection of flagellin positively and negatively regulates salmonella infection.Semantic proximity Read ↗

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