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Article

Generating double knockout mice to model genetic intervention for diabetic cardiomyopathy in humans.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2014

Chavali Vishalakshi, Nandi Shyam Sundar, Singh Shree Ram, Mishra Paras Kumar

Abstract excerpt

Diabetes is a rapidly increasing disease that enhances the chances of heart failure twofold to fourfold (as compared to age and sex matched nondiabetics) and becomes a leading cause of morbidity and mortality. There are two broad classifications of diabetes: type1 diabetes (T1D) and type2 diabetes (T2D). Several mice models mimic both T1D and T2D in humans. However, the genetic intervention to ameliorate diabetic...

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Identifiers

PMID: 25064116
DOI: 10.1007/978-1-4939-1215-5_22
PMCID: PMC7218297

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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