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Article

Classical V600E and other non-hotspot BRAF mutations in adult differentiated thyroid cancer.

Journal of translational medicine - 7 Jul 2016

Murugan Avaniyapuram Kannan, Qasem Ebtesam, Al-Hindi Hindi, Shi Yufei, Alzahrani Ali S

Abstract excerpt

BACKGROUND: BRAF is the most frequently mutated gene in differentiated thyroid cancer (DTC). Previous studies on DTC have well documented high rates of the BRAF (V600E) mutation in patients of mixed ages. Previous studies either included a mix of pediatric and adult patients or pediatric patients only. However, the prevalence of hotspot and non-hotspot BRAF mutations and its significance in pure adult DTCs is not...

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Identifiers

PMID: 27387551
DOI: 10.1186/s12967-016-0958-x
PMCID: PMC4936197

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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