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Article

The influence of age-independent somatic driver alterations on clinical outcomes in paediatric and young adult thyroid cancer.

European thyroid journal - 1 Feb 2026

Canberk Sule, Isaza Amber, Bojarsky Mya, Simplício Mariana, Barroca Helena, Akkoyunlu Serra Z, Günver Güven, Almeida Isabel, Dello Iacovo Filippo, Carillo Anna M, Nacchio Mariantonia, Vigliar Elena, Bellevicine Claudio, Troncone Giancarlo, Larkin Riley, Belcher Ryan H, Weiss Vivian, Wang Huiying, Baloch Zubair, Schmitt Fernando, Bauer Andrew

Abstract excerpt

Background: Paediatric and young adult differentiated thyroid carcinoma (DTC) often presents at an advanced stage but carries an excellent prognosis. While age-related genomic differences from adult DTC are recognized, it remains unclear whether outcomes are driven by age or tumour biology. Methods: We analysed a multi-institutional cohort of 363 patients aged 0-25 years who underwent molecular testing and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41499172
DOI: 10.1530/ETJ-25-0310
PMCID: PMC13138597

Genes

BRAF
NTRK1
RET
DICER1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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