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Article

Early-life nutrition modulates the epigenetic state of specific rDNA genetic variants in mice.

Science (New York, N.Y.) - 29 Jul 2016

Holland Michelle L, Lowe Robert, Caton Paul W, Gemma Carolina, Carbajosa Guillermo, Danson Amy F, Carpenter Asha A M, Loche Elena, Ozanne Susan E, Rakyan Vardhman K

Abstract excerpt

A suboptimal early-life environment, due to poor nutrition or stress during pregnancy, can influence lifelong phenotypes in the progeny. Epigenetic factors are thought to be key mediators of these effects. We show that protein restriction in mice from conception until weaning induces a linear correlation between growth restriction and DNA methylation at ribosomal DNA (rDNA). This epigenetic response remains into...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27386920
DOI: 10.1126/science.aaf7040
PMCID: PMC5734613

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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