Article
Genetic variation at mouse and human ribosomal DNA influences associated epigenetic states.
Genome biology - 14 Feb 2022
Rodriguez-Algarra Francisco, Seaborne Robert A E, Danson Amy F, Yildizoglu Selin, Yoshikawa Harunori, Law Pui Pik, Ahmad Zakaryya, Maudsley Victoria A, Brew Ama, Holmes Nadine, Ochôa Mateus, Hodgkinson Alan, Marzi Sarah J, Pradeepa Madapura M, Loose Matthew, Holland Michelle L, Rakyan Vardhman K
Abstract excerpt
BACKGROUND: Ribosomal DNA (rDNA) displays substantial inter-individual genetic variation in human and mouse. A systematic analysis of how this variation impacts epigenetic states and expression of the rDNA has thus far not been performed. RESULTS: Using a combination of long- and short-read sequencing, we establish that 45S rDNA units in the C57BL/6J mouse strain exist as distinct genetic haplotypes that...
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