Article
Maternal one-carbon metabolism, MTHFR and TCN2 genotypes and neural tube defects in India.
Birth defects research. Part A, Clinical and molecular teratology - 1 Sept 2011
Godbole Koumudi, Gayathri Panjalingam, Ghule Smita, Sasirekha Batchu Venkatanaga, Kanitkar-Damle Amruta, Memane Nilam, Suresh Seshadri, Sheth Jayesh, Chandak Giriraj Ratan, Yajnik Chittaranjan S
Abstract excerpt
BACKGROUND: Neural tube defects (NTDs) are among the most common severe congenital malformations, representing a long-term public health burden in India. A deranged one-carbon metabolism and genes regulating this metabolism have been linked to NTDs. Vitamin B(12) deficiency is reported to be more prevalent than folate deficiency in the Indian population. We investigated the role of maternal nutritional and...
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