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Article

[Methylenetetrahydrofolate reductase polymorphisms as risk factors for myelomeningocele].

Revista medica de Chile - 1 May 2014

Pardo Rosa, Suazo José, Castillo Silvia, Vargas Marcela, Zalavari Andrea, Santos José Luis, Blanco Rafael, Rotter Karin, Solar Margarita, Tapia Eva

Abstract excerpt

BACKGROUND: Mandatory fortification with folic acid (FA) was implemented in Chile in 2000. Thereafter, the rate of spina bifida decreased by 52 to 55%. Genetic abnormalities in folate metabolism may be involved in the etiology of spina bifida. AIM: To evaluate the association between myelomeningocele (MM) and c.A1298C and c.C677T polymorphisms within the coding gene for 5,10-methylenetetrahydrofolate reductase...

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Identifiers

PMID: 25427015
DOI: 10.4067/S0034-98872014000500006

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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[Methylenetetrahydrofolate reductase polymorphisms as risk factors for myelomeningocele].PMID 25427015Read ↗

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[Frequency of C677T polymorphism of 5, 10-methylenetetrahydrofolate reductase (MTHFR) in Chilean mothers of spina bifida cases and controls ].Semantic proximity Read ↗

Urinary tract anomalies associated with MTHFR gene polymorphism C677T in girls.Semantic proximity Read ↗

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