Article
Identification of novel candidate risk genes for myelomeningocele within the glucose homeostasis/oxidative stress and folate/one-carbon metabolism networks.
Molecular genetics & genomic medicine - 1 Nov 2020
Hillman Paul, Baker Craig, Hebert Luke, Brown Michael, Hixson James, Ashley-Koch Allison, Morrison Alanna C, Northrup Hope, Au Kit Sing
Abstract excerpt
BACKGROUND: Neural tube defects (NTDs) are the second most common complex birth defect, yet, our understanding of the genetic contribution to their development remains incomplete. Two environmental factors associated with NTDs are Folate and One Carbon Metabolism (FOCM) and Glucose Homeostasis and Oxidative Stress (GHOS). Utilizing next-generation sequencing of a large patient cohort, we identify novel candidate...
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