Analyzing Neisseria gonorrhoeae Pilin Antigenic Variation Using 454 Sequencing Technology.

Abstract excerpt

UNLABELLED: Many pathogens use homologous recombination to vary surface antigens in order to avoid immune surveillance. Neisseria gonorrhoeae, the bacterium responsible for the sexually transmitted infection gonorrhea, achieves this in part by changing the sequence of the major subunit of the type IV pilus in a process termed pilin antigenic variation (Av). The N. gonorrhoeae chromosome contains one expression...

Topics

• Amino Acid Sequence
• Antigenic Variation
• Antigens, Bacterial
• Fimbriae Proteins
• Gene Expression Regulation, Bacterial
• Mutation
• Neisseria gonorrhoeae