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Article

Publicly Available Neisseria Gonorrhoeae Genomes Predominantly Represent In Vitro-Derived Nonpiliated Variants.

The Journal of infectious diseases - 18 Feb 2026

Boiko Iryna, Metaane Selma, Seifert H Steven

Abstract excerpt

BACKGROUND: The Neisseria gonorrhoeae pilE gene encodes the PilE protein, the major subunit of the Type IV pilus and a primary colonization and virulence factor. The pilE gene undergoes high-frequency diversification mainly through gene conversion from one of many pilS copies. These unique molecular processes contribute to gonococcal population diversity, facilitating immune evasion. While the process of pilin...

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Identifiers

PMID: 41334759
DOI: 10.1093/infdis/jiaf557
PMCID: PMC13017665

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