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Article

The frequency and rate of pilin antigenic variation in <i>Neisseria gonorrhoeae</i>

13 Sept 2005

Abstract excerpt

The pilin antigenic variation (Av) system of Neisseria gonorrhoeae (Gc) mediates unidirectional DNA recombination from silent gene copies into the pilin expression locus. A DNA sequencing assay was developed to accurately measure pilin Av in a population of Gc strain FA1090 arising from a defined pilin progenitor under non-selective culture conditions. This assay employs a piliated parental Gc variant with a recA...

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Identifiers

PMID: 16194236
DOI: 10.1111/j.1365-2958.2005.04838.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The frequency and rate of pilin antigenic variation in <i>Neisseria gonorrhoeae</i>PMID 16194236Read ↗

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Analyzing Neisseria gonorrhoeae Pilin Antigenic Variation Using 454 Sequencing Technology.Semantic proximity Read ↗

An Alternative DNA Structure Is Necessary for Pilin Antigenic Variation in <i>Neisseria gonorrhoeae</i>Semantic proximity Read ↗

CRISPRi targeting to the Neisseria gonorrhoeae R-loop or G4 mutant region restores pilin antigenic variation.Semantic proximity Read ↗

Pilin antigenic variation occurs independently of the RecBCD pathway in Neisseria gonorrhoeae.Semantic proximity Read ↗

Antigenic variation of gonococcal pilin expression in vivo: analysis of the strain FA1090 pilin repertoire and identification of the pilS gene copies recombining with pilE during experimental human infection The GenBank accession numbers for the sequences reported in this paper are U58840–U58851, U61269, L28978, L28980, L28987 and L28990–L28992.Semantic proximity Read ↗

Pilin gene variation inNeisseria gonorrhoeae: reassessing the old paradigmsSemantic proximity Read ↗

Loss of both Holliday junction processing pathways is synthetically lethal in the presence of gonococcal pilin antigenic variationSemantic proximity Read ↗

Diversity and evolution of a phase-variable multi-locus antigen in <i>Neisseria gonorrhoeae</i>Semantic proximity Read ↗

Questions about gonococcal pilus phase‐ and antigenic variationSemantic proximity Read ↗

Publicly Available Neisseria Gonorrhoeae Genomes Predominantly Represent In Vitro-Derived Nonpiliated Variants.Semantic proximity Read ↗

Altering the Neisseria gonorrhoeae pilE Guanine Quadruplex Loop Bases Affects Pilin Antigenic Variation.Semantic proximity Read ↗

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