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Article

Diversity and evolution of a phase-variable multi-locus antigen in Neisseria gonorrhoeae.

PLoS pathogens - 1 May 2026

Yu QinQin, Mortimer Tatum D, Blomqvist Sofia O P, Bowcutt Bailey, Helekal David, Palace Samantha G, Grad Yonatan H

Abstract excerpt

Neisseria gonorrhoeae is a sexually transmitted bacterial pathogen that deploys multiple mechanisms to evade the immune system, including rapid variation in surface antigens. One of the most abundant and diverse antigens is a member of the opacity-associated (Opa) family, which includes surface proteins that mediate gonococcal attachment to human receptors. Studies of Opa diversity and evolution have been limited...

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Identifiers

PMID: 42113870
DOI: 10.1371/journal.ppat.1013962
PMCID: PMC13183285

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