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Article

An Alternative DNA Structure Is Necessary for Pilin Antigenic Variation in <i>Neisseria gonorrhoeae</i>

6 Aug 2009

Abstract excerpt

Pathogens can use DNA recombination to promote antigenic variation (Av) of surface structures to avoid immune detection. We identified a cis-acting DNA sequence near the antigenically variable pilin locus of the human pathogen, Neisseria gonorrhoeae. This 16-base pair guanine (G)-rich sequence was required for pilin Av and formed a guanine quartet (G4) structure in vitro. Individual mutations that disrupted the...

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PMID: 19661435
DOI: 10.1126/science.1175653

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An Alternative DNA Structure Is Necessary for Pilin Antigenic Variation in <i>Neisseria gonorrhoeae</i>PMID 19661435Read ↗

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