Epithelial-mesenchymal transition (EMT) phenotype at invasion front of squamous cell carcinoma of the penis influences oncological outcomes.

doi:10.1016/j.urolonc.2016.05.015

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Epithelial-mesenchymal transition (EMT) phenotype at invasion front of squamous cell carcinoma of the penis influences oncological outcomes.

Urologic oncology - 1 Oct 2016

da Cunha Isabela Werneck, Souza Maria José L, da Costa Walter Henriques, Amâncio Alice M, Fonseca Francisco Paulo, Zequi Stenio de Cassio, Lopes Ademar, Guimarães Gustavo Cardoso, Soares Fernando

Abstract excerpt

OBJECTIVE: Our aims were to evaluate epithelial-mesenchymal transition (EMT) as a useful prognostic marker in penile carcinoma (PC), and establish an objective criterion to define EMT in PC specimens. MATERIALS AND METHODS: A total of 149 consecutive cases surgically treated for PC were retrospectively selected. E-cadherin (E-CAD) and vimentin immunohistochemical expressions were evaluated. A combined analysis...

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Epithelial-mesenchymal transition (EMT) phenotype at invasion front of squamous cell carcinoma of the penis influences oncological outcomes.

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