Article
Epithelial to mesenchymal transition markers are associated with an increased metastatic risk in primary cutaneous squamous cell carcinomas but are attenuated in lymph node metastases.
Journal of dermatological science - 1 Nov 2013
Toll Agustí, Masferrer Emili, Hernández-Ruiz M E, Ferrandiz-Pulido Carla, Yébenes Mireia, Jaka Ane, Tuneu Anna, Jucglà Anna, Gimeno Javier, Baró Teresa, Casado Beatriz, Gandarillas Alberto, Costa Irmgard, Mojal Sergi, Peña Raul, de Herreros Antonio García, García-Patos Vicenç, Pujol Ramon M, Hernández-Muñoz Inmaculada
Abstract excerpt
BACKGROUND: Cutaneous squamous cell carcinoma (cSCC) is the second most common malignancy in humans and approximately 5% metastasize, usually to regional lymph nodes. Epithelial to mesenchymal transition (EMT) is a process involving loss of intercellular adhesion, acquisition of a mesenchymal phe...
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