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Article

Reality of Single Circulating Tumor Cell Sequencing for Molecular Diagnostics in Pancreatic Cancer.

The Journal of molecular diagnostics : JMD - 1 Sept 2016

Court Colin M, Ankeny Jacob S, Sho Shonan, Hou Shuang, Li Qingyu, Hsieh Carolyn, Song Min, Liao Xinfang, Rochefort Matthew M, Wainberg Zev A, Graeber Thomas G, Tseng Hsian-Rong, Tomlinson James S

Abstract excerpt

To understand the potential and limitations of circulating tumor cell (CTC) sequencing for molecular diagnostics, we investigated the feasibility of identifying the ubiquitous KRAS mutation in single CTCs from pancreatic cancer (PC) patients. We used the NanoVelcro/laser capture microdissection CTC platform, combined with whole genome amplification and KRAS Sanger sequencing. We assessed both KRAS codon-12...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplastic Cells, Circulating

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Share to Proto-Oncogene Proteins p21(ras)

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Source

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Identifiers

PMID: 27375074
DOI: 10.1016/j.jmoldx.2016.03.006
PMCID: PMC5397706

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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